Led by the School of Design at Queensland University of Technology, the Design for Change initiative is a ground-breaking program that leverages innovation to drive meaningful changes and improve the quality of life and well-being for all beings and the environment. Established in 2014, it began as a study tour between Australian and Singaporean Universities supported by the Singapore Government and funded by the Australian Government, New Colombo Plan Scholarship program to support the creation of healthcare innovations in Singapore and Australia. It has since grown into a global movement. This initiative engages researchers, academics, governments, industry and the public to tackle complex social, economic, and environmental challenges through innovative and impactful collaborations with a program of intensive bootcamps, design sprints, exhibitions, and international symposiums. Our 2023 “Better Health for All” and 2024 “Sustainability in Healthcare” symposiums, design sprints, and study tours aligned with UN Sustainability Goals. To create universal design solutions, we have brought together over 200 design, health, engineering, business, science and IT students from eight universities and academics and experts from Australia, Malaysia, Singapore, Taiwan, Thailand, Hong Kong, UAE and UK. To date, 30+ creative solutions have been generated including universal design solutions for better access to services and support for individuals living with disabilities, innovative educational campaigns for disease prevention, multi-lingual communication platforms for better healthcare information and translation, transformational spaces to support well-being outcomes for neurodiverse populations and digital tools for better distribution of pharmaceuticals to the ageing population. We continue to push the boundaries of innovation through transdisciplinary, cross-cultural collaboration to address global challenges. By fostering a global network of collaborators at the frontiers of design and innovation, Design for Change is creating a sustainable, accessible and equitable future for all.